MAVE educational resources

Thinking about incorporating Multiplex Assays of Variant Effect (MAVE)s into your work?

Check out the resources below to get started!

MAVE-Relevant Reviews

Thinking about incorporating MAVEs into your work? Here are useful MAVE-relevant reviews.

Tabet D., Parikh V., Mali P., Roth F.P. & Claussnitzer M. Scalable functional assays for the interpretation of human genetic variation. Annu Rev Genet. 2022.
Geck R.C., Boyle G., Amorosi C.J., Fowler D.M. & Dunham M.J. Measuring pharmacogene variant function at scale using multiplexed assays. Annu Rev Pharmacol Toxicol. 2022.
Findlay G.M. Linking genome variants to disease: scalable approaches to test the functional impact of human mutations. Hum Mol Genet. 2021. Kinney J.B. & McCandlish D.M. Massively parallel assays and quantitative sequence-function relationships. Annu Rev Genom Hum Genet. 2019.
Weile J. & Roth F.P. Multiplexed assays of variant effects contribute to a growing genotype–phenotype atlas. Hum Genet. 2018.
Starita L.M., Ahituv N., Dunham M.J., Kitzman J.O., Roth F.P., Seelig G., Shendure J. & Fowler D.M. Variant interpretation: functional assays to the rescue. Am J Hum Genet. 2017.
Gasperini M., Starita L. & Shendure J. The power of multiplexed functional assays of genetic variants. Nat Protoc. 2016.

Technology & methods development manuscripts

Designing a MAVE? >>Follow this link<< to view granular reviews and seminal papers relevant to methods at each stage of the MAVE development process.

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The MAVE -Relevant Review and Technology and Methods resource is provided by the Experimental Technology and Standards (ETS) workstream. If there is a critical review, stage or category of MAVE experimental design or technology that you think should be included here, please tell us at this link: Google Sheet