Mutational Scanning Symposium 2023

Mutational Scanning Symposium 2023

Bringing function to the genome

When: July 13 &14, 2023

Where: Wellcome Genome Campus, UK and Virtual

Program: Can be found HERE

Event Hashtag: #VariantEffect23 

About: Mutational scanning technologies and Multiplex Assays of Variant Effects (MAVEs) are key to variant interpretation and transform our understanding of the human genome.

At the 6th annual meeting of the ‘Mutational Scanning Symposium’, experts in the fields of functional genomics, protein science, precision medicine, variant interpretation, and computational genetics came from around the world to meet, present their work, discuss new methods and provide insights on the future of this science.

The conference was a two-day hybrid meeting with onsite or virtual attendance. Discussions centered on a variety of exciting topics, including computational variant effect prediction, saturation mutagenesis, sequence/structure/function relationships, high throughput assays and protein engineering. There were focused discussions how to apply functional data to clinical practice along with conversations about emerging technologies for functional assays.

Speakers included:

Frederick Roth University of Toronto, Canada (KEYNOTE)

Leslie G. Biesecker NIH-National Human Genome Research Institute, USA

Erika Alden DeBenedictis The Francis Crick Institute, UK

Liselot Dewachter  KU Leuven, Belgium

Mafalda Dias Centre for Genomic Regulation, Spain

Diane Dickel Octant Bio, USA

Greg Findlay The Francis Crick Institute, UK

Irene Gallego Romero University of Melbourne , Australia

Isaac Jia  Greater Bay Area Institute of Precision Medicine, China

Ben Lehner Wellcome Sanger Institute, UK

Victoria Parikh Stanford University, USA

Gabriel Rocklin Northwestern University, USA

Raghavan Varadarajan Indian Institute of Science, India

You can find the final programme for the conference >>> HERE

Thank you to this year’s event sponsors!

By the Numbers summary of the 2023 Mutational Scanning Symposium . Graphics credit: Freepik and Alex Cagan

Pre and Post Event Press

• Building an atlas of gene variants to understand health and disease - Wellcome Sanger Institute Blog - Summary from the 6th Annual Mutational Scanning Symposium
• Following Up on MSS 2023: Perspectives from Two Participants -Q&A with Drs. Raghavan Varadarajan and Yann Ilboudo.
• Exploring variant effects to advance precision medicine - Post event synopsis by Dr Sounak Sahu
• Collection of Alex Cagan Illustrations from the Symposium
• Q&A with Invited speaker Dr. Xiaoyan “Isaac” Jia
• What to Expect at the MSS 2023 Symposium July 13 and 14 in UK: A Q&A with Keynote Speaker Dr. Frederick (Fritz) Roth
• MSS 2023 Planners Explore Expected Symposium Highlights and Opportunities with Drs. Clare Turnbull and David Adams

Planning committee members and organizers

David Adams (he/him) Wellcome Sanger Institute, UK
Matthew Hurles (he/him) Wellcome Sanger Institute, UK
Lara Muffley (she/her) University of Washington, USA
Lea Starita (she/her) University of Washington, USA
Clare Turnbull (she/her) The Institute of Cancer Research, UK
Amanda Fletcher (she/her) Wellcome Connecting Science Conference & Events Organiser
Nagehan Ramazanoglu Bahadir (she/her) Wellcome Connecting Science Scientific Programme Officer