Biography
Jonuelle (Jon) Acosta is a postdoctoral fellow at MIT co-mentored by Francisco Sánchez-Rivera and Michael Hemann. He completed his PhD at the University of Pennsylvania in David Feldser's laboratory, where he utilized tractable mouse models of cancer to model the impact of p53 restorative therapies in small cell carcinoma. As an F31 predoctoral fellow, he identified novel context-dependent mechanisms of p53-mediated tumor suppression that may be utilized to develop novel strategies to treat this aggressive cancer subtype, and others. During his postdoctoral work, he is integrating next-generation genome editing technology with complex ex vivo and in vivo platforms to understand how cellular context influences genetic interactions, and its impact on cancer progression and evolution.
Employer
MIT
Seminars
Multiplexed in vivo base editing identifies functional gene-variant-context interactions