MAVE resources

Multiplexed assays of variant effects (MAVEs) allow us to assess (in a single experiment) thousands of variants simultaneously. This technique, which harnesses the power of next-gen sequencing, yields large-scale data sets that can shed light on the functional consequences of protein variants and ultimately on the the landscape of human genetic variation. We are currently working on providing a comprehensive MAVE knowledge base. We hope these preliminary resources will be a helpful starting place!

If you are interested in helping to further develop this resource, please contact program manager Lara Muffley (muffley@uw.edu)

MaveDB
A public repository for variant effect maps
MAVE registry
A collaborative resource for sharing progress on MAVEs
MAVE impute
Impute missing data for variant effect maps
MAVE pipelines
Pacbio barcode clustering  TileSeq analysis pipeline for MAVEs

So you want to make (or use!) a variant effect map…

What tools do I need? What variables should I consider? How do I get started?

Educational Resources (clinical application)

Educational Resources (experimental)

  • Comprehensive MAVE-relevant reviews Thinking about incorporating MAVEs into your work? Visit our MAVE educational resources page to find comprehensive MAVE-relevant reviews.
  • Technology and methods development manuscripts Designing a MAVE? >>Follow this link<< to view granular reviews and seminal papers relevant to methods at each stage of the MAVE development process.

Experimental Protocols

New! MAVE protocols collection in protocols.io.

https://www.protocols.io/workspaces/atlas-of-variant-effects-alliance

To add your protocol to the collection, please read this how-to guide or watch this how-to-video.

Educational Videos

Computational Resources

Monthly Seminar / Annual Meeting

Discussion Forums

Atlas of Variant Effects Alliance community slack channel (https://www.varianteffect.org/membership/)