VARIANT EFFECTS SEMINAR SERIES (VESS)

In this series, early-career scientists from around the globe share and discuss their research related to interpreting human genetic variation.

 

NEXT SEMINAR: February 4th, 2025

9-10am Pacific timezone converter

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Toni Beltran

Center for Genomic Regulation (CRG)

Presentation Date: February 4th, 2025

Title: Mutating the human domainome

BIO: I'm a Postdoc at Lehner lab at CRG Barcelona interested in understanding the language of proteins - how their sequence determines their biochemical properties and functions. In my postdoc I have focused on multiplexed deep mutational scans of human protein domains, and on combining DMS with multiple molecular readouts to understand allosteric communication in kinases. Before joining the variant bio world I worked on quantifying the dynamics and stability of heritable epigenetic states by sequencing many generations of isogenic worms as a PhD student at the MRC-LMS (Imperial College London). I enjoy the combination of large-scale experimentation and computational analysis to understand fundamental biological questions.

 

pronouns: he/him

twitter username: @mutatoni


Alexandra Bendel

Ecole  Polytechnique Fédérale de Lausanne (EPFL)

Presentation Date: February 4th, 2025

Upcoming Speakers:

Zachary Walsh

Columbia University

Presentation Date: March 4th, 2025

Title: Massively scalable assessment of variant effects in primary human T cells.

Pronouns: he/him

Speaker Bio: Zach is a 5th-year MD/PhD candidate at Columbia University Vagelos College of Physicians and Surgeons. He is currently completing his PhD in Benjamin Izar's lab, where he works at the intersection of T cell engineering and human genetics. His current work involves the scalable generation and discovery of variants that enhance T-cell based cancer therapies using CRISPR base editing screens.

 

Social: @zwalsh96

SEMINAR SERIES FAQs

    • 1st Tuesday of each month (9am Pacific)

    • Start time is 9am, 12pm, 2am, 4pm (Pacific, Eastern, Australia East, UTC)

    • We have members and presenters from around the globe (multiple time zones)

    • Our seminars are one hour long and are free and open to the public.

  • Early career scientists: Students, postdocs, and new faculty (<1 year in position)

    If you are interested in presenting or would like to recommend someone, please fill out this online > SPEAKER NOMINATION FORM

    • One hour long virtual meetings (zoom)

    • Each month, two presenters discuss their work in 20-minute talks, followed by lively Q&A sessions.

    • Questions from the audience can be asked using chat or Q&A during the webinar

    • Our meetings are over Zoom and anyone is welcome to attend.

    • We use the webinar format, but participants can ask the speaker questions using the chat or Q&A

    • Anyone can attend. However, if you are interested in becoming a member of the Alliance, please sign up > HERE

  • The Variant Effect Seminar Series Committee members are listed here https://www.varianteffect.org/vess-committee

    • Speakers can also now link their VESS talks to bioRxiv preprints!

    • You can also find a list of previous speakers and talks > HERE

Future Seminars:

We are looking for speakers, including students, postdocs, and new faculty (<1 year in position)!!

If you are interested in presenting or would like to recommend someone, please fill out this online >> SPEAKER NOMINATION FORM

or contact one of the VESS Organizers on our AVE slack channel!

(sign up to become a member and join conversations on slack https://www.varianteffect.org/membership)